During the XVI century Georgia found itself trapped between two expanding empires, the Ottoman Turks from the West and the Persians from the East. The fall of Constantinople and the corresponding change in trade routes greatly weakened Georgia and its future was in grave peril.
The Persian Shah Tahmasp invaded Georgia four times and Tbilisi was captured and many slaves were taken (Georgian women were very valued for their beauty and men were valued as economic advisors). Eventually the kingdom was divided into two spheres of influence, the West to the Turks and the East to the Persians. For the next 250 years Georgia was unable to regain the independence.